Pre-clinical dose-ranging efficacy, pharmacokinetics, tissue biodistribution, and toxicity of a targeted contrast agent for MRI of amyloid deposition in Alzheimer’s disease

In these preclinical studies, we describe ADx-001, an Aβ-targeted liposomal macrocyclic gadolinium (Gd) imaging agent, for MRI of amyloid plaques. The targeting moiety is a novel lipid-PEG conjugated styryl-pyrimidine. An MRI-based contrast agent such as ADx-001 is attractive because of the lack of...

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Udgivet i:Sci Rep
Main Authors: Badachhape, Andrew A., Working, Peter K., Srivastava, Mayank, Bhandari, Prajwal, Stupin, Igor V., Devkota, Laxman, Tanifum, Eric A., Annapragada, Ananth V., Ghaghada, Ketan B.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527957/
https://ncbi.nlm.nih.gov/pubmed/32999398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73233-7
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