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A Novel liposomal nanoparticle for the imaging of amyloid plaque by MRI
Amyloid binding molecules with greater hydrophilicity than existing ligands were synthesized. The lead candidate ET6-21 bound amyloid fibrils, and amyloid deposits in dog brain and human brain tissue ex vivo. The ligand was used to prepare novel amyloid-targeted liposomal nanoparticles. The preparat...
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| Publicado no: | J Alzheimers Dis |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4931553/ https://ncbi.nlm.nih.gov/pubmed/27031484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-151124 |
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