Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung

LAMP2A and HSC70 are crucial players in chaperone-mediated autophagy (CMA), a targeted, lysosome-dependent protein degradation pathway. Elevated LAMP2A levels, indicative of increased CMA activity, are observed in several malignancies, and CMA downregulation may be exploited therapeutically. We eval...

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Bibliografiske detaljer
Udgivet i:Oxid Med Cell Longev
Main Authors: Losmanová, Tereza, Janser, Félice A., Humbert, Magali, Tokarchuk, Igor, Schläfli, Anna M., Neppl, Christina, Schmid, Ralph A., Tschan, Mario P., Langer, Rupert, Berezowska, Sabina
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527932/
https://ncbi.nlm.nih.gov/pubmed/33029283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/8506572
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