Hepatic Stellate Cell–Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury

Platelet-derived growth factor receptor (PDGFR)-α plays roles in cell survival, proliferation, and differentiation; however, its function in chronic liver injury sequelae, such as fibrosis, is unknown. Hepatic stellate cells (HSCs), the primary mediators of fibrosis, undergo activation, which entail...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Kikuchi, Alexander, Singh, Sucha, Poddar, Minakshi, Nakao, Toshimasa, Schmidt, Heidi Marie, Gayden, Jenesis D., Sato, Toshifumi, Arteel, Gavin E., Monga, Satdarshan P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2020
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527859/
https://ncbi.nlm.nih.gov/pubmed/32615075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.06.006
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