Pancreatic and duodenal homeobox-1 (PDX1) contributes to β-cell mass expansion and proliferation induced by Akt/PKB pathway

Maintenance of pancreatic β-cell mass and function is fundamental to glucose homeostasis and to prevent diabetes. The PI3 K-Akt-mTORC1 pathway is critical for β-cells mass and function, while PDX1 has been implicated in β-cell development, maturation, and function. Here we tested whether Akt signali...

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Bibliografiske detaljer
Udgivet i:Islets
Main Authors: Jara, Mark Anthony, Werneck-De-Castro, Joao Pedro, Lubaczeuski, Camila, Johnson, James D., Bernal-Mizrachi, Ernesto
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527019/
https://ncbi.nlm.nih.gov/pubmed/32876522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19382014.2020.1762471
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