Filovirus Antiviral Activity of Cationic Amphiphilic Drugs Is Associated with Lipophilicity and Ability To Induce Phospholipidosis

Several cationic amphiphilic drugs (CADs) have been found to inhibit cell entry of filoviruses and other enveloped viruses. Structurally unrelated CADs may have antiviral activity, yet the underlying common mechanism and structure-activity relationship are incompletely understood. We aimed to unders...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Gunesch, Antonia P., Zapatero-Belinchón, Francisco J., Pinkert, Lukas, Steinmann, Eike, Manns, Michael P., Schneider, Gisbert, Pietschmann, Thomas, Brönstrup, Mark, von Hahn, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526846/
https://ncbi.nlm.nih.gov/pubmed/32513799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00143-20
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