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Analysis of Paradoxical Efficacy of Carbapenems against Carbapenemase-Producing Escherichia coli in a Murine Model of Lethal Peritonitis

The clinical benefit of carbapenems against carbapenemase-producing Enterobacteriaceae (CPE) remains in question. MICs of imipenem (IMP) and ertapenem (ERT) against isogenic derivatives of the wild-type strain Escherichia coli CFT073 producing KPC-3, OXA-48, or NDM-1 were 0.25, 2, 16, and 64 mg/lite...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Roujansky, Ariane, de Lastours, Victoire, Guérin, François, Chau, Françoise, Cheminet, Geoffrey, Massias, Laurent, Cattoir, Vincent, Fantin, Bruno
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526833/
https://ncbi.nlm.nih.gov/pubmed/32423956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00853-20
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