617. Efficacy of Dimercaptosuccinic Acid (DMSA), a Zinc Chelator, in Combination with Imipenem Against Metallo-β-Lactamase Producing Escherichia coli in a Murine Peritonitis Model

BACKGROUND: A strategy used by bacterial strains to resist β-lactam antibiotics is the expression of metallo-β-lactamases (MBL) requiring zinc for activity. The use of a zinc chelator may restore carbapenem activity against MBL-producing Enterobacteriaceae. DMSA is a heavy metal chelator approved in...

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Publicat a:Open Forum Infect Dis
Autors principals: Cheminet, Geoffrey, Nordmann, Patrice, Chau, Francoise, Kieffer, Nicolas, Peoc’h, Katell, Massias, Laurent, de Lastours, Victoire, Fantin, Bruno
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811259/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.685
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