Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration

In order to prioritize available immune therapeutics, immune profiling across glioma grades was conducted, followed by preclinical determinations of therapeutic effect in immune-competent mice harboring gliomas. T cells and myeloid cells were isolated from the blood of healthy donors and the blood a...

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Vydáno v:JCI Insight
Hlavní autoři: Ott, Martina, Tomaszowski, Karl-Heinz, Marisetty, Anantha, Kong, Ling-Yuan, Wei, Jun, Duna, Maya, Blumberg, Katia, Ji, Xiaorong, Jacobs, Carmen, Fuller, Gregory N., Langford, Lauren A., Huse, Jason T., Long, James P., Hu, Jian, Li, Shulin, Weinberg, Jeffrey S., Prabhu, Sujit S., Sawaya, Raymond, Ferguson, Sherise, Rao, Ganesh, Lang, Frederick F., Curran, Michael A., Heimberger, Amy B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526457/
https://ncbi.nlm.nih.gov/pubmed/32721947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134386
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