Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes

Dysregulated sensing of self–nucleic acid is a leading cause of autoimmunity in multifactorial and monogenic diseases. Mutations in Wiskott-Aldrich syndrome protein (WASp), a key regulator of cytoskeletal dynamics in immune cells, cause autoimmune manifestations and increased production of type I IF...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Piperno, Giulia Maria, Naseem, Asma, Silvestrelli, Giulia, Amadio, Roberto, Caronni, Nicoletta, Cervantes-Luevano, Karla Evelia, Liv, Nalan, Klumperman, Judith, Colliva, Andrea, Ali, Hashim, Graziano, Francesca, Benaroch, Philippe, Haecker, Hans, Hanna, Richard N., Benvenuti, Federica
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526445/
https://ncbi.nlm.nih.gov/pubmed/32721945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132857
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