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Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease

BACKGROUND: Hypothalamic dysfunction occurs early in the clinical course of Alzheimer’s disease (AD), likely contributing to disturbances in feeding behavior and metabolic function that are often observed years prior to the onset of cognitive symptoms. Late-life weight loss and low BMI are associate...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Robison, Lisa S., Gannon, Olivia J., Thomas, Melissa A., Salinero, Abigail E., Abi-Ghanem, Charly, Poitelon, Yannick, Belin, Sophie, Zuloaga, Kristen L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526387/
https://ncbi.nlm.nih.gov/pubmed/32993686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01956-5
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