Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage

Fusobacterium nucleatum (Fn) is frequently found in colorectal cancers (CRCs). High loads of Fn DNA are detected in CRC tissues with microsatellite instability-high (MSI-H), or with the CpG island hypermethylation phenotype (CIMP). Fn infection is also associated with the inflammatory tumor microenv...

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Bibliographic Details
Published in:Gut Pathog
Main Authors: Okita, Yoshiki, Koi, Minoru, Takeda, Koki, Ross, Ryan, Mukherjee, Bhramar, Koeppe, Erika, Stoffel, Elena M., Galanko, Joseph A., McCoy, Amber N., Keku, Temitope O., Okugawa, Yoshinaga, Kitajima, Takahito, Toiyama, Yuji, Martens, Eric, Carethers, John M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Letter to the Editor
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526104/
https://ncbi.nlm.nih.gov/pubmed/33005238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13099-020-00384-3
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