Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis

The orexigenic peptide ghrelin (Ghr) stimulates hunger signals in the hypothalamus via growth hormone secretagogue receptor (GHS-R1a). Gastric Ghr is synthetized as a preprohormone which is proteolytically cleaved, and acylated by a membrane-bound acyl transferase (MBOAT). Circulating Ghr is reduced...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Petrescu, Anca D., Grant, Stephanie, Williams, Elaina, Frampton, Gabriel, Reinhart, Evan H., Nguyen, Amy, An, Suyeon, McMillin, Matthew, DeMorrow, Sharon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525536/
https://ncbi.nlm.nih.gov/pubmed/32994489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72681-5
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