Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling

BACKGROUND: Wisteria floribunda agglutinin (WFA)(+) Mac-2-binding protein (M2BPGi) is a novel serum marker for liver fibrosis. Although an elevated serum level of M2BPGi can predict development of hepatocellular carcinoma (HCC), the effect of M2BPGi on HCC remains unclear. There are no reports about...

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Published in:Br J Cancer
Main Authors: Dolgormaa, Gantumur, Harimoto, Norifumi, Ishii, Norihiro, Yamanaka, Takahiro, Hagiwara, Kei, Tsukagoshi, Mariko, Igarashi, Takamichi, Watanabe, Akira, Kubo, Norio, Araki, Kenichiro, Handa, Tadashi, Yokobori, Takehiko, Oyama, Tetsunari, Kuwano, Hiroyuki, Shirabe, Ken
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525442/
https://ncbi.nlm.nih.gov/pubmed/32624579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0971-y
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