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Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells

Living cells and tissues experience various complex modes of forces that are important in physiology and disease. However, how different force modes impact gene expression is elusive. Here we apply local forces of different modes via a magnetic bead bound to the integrins on a cell and quantified ce...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Wei, Fuxiang, Xu, Xiangyu, Zhang, Cunyu, Liao, Yawen, Ji, Baohua, Wang, Ning
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524734/
https://ncbi.nlm.nih.gov/pubmed/32994402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18584-5
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