Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients

Late-onset inflammatory toxicities resembling hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS) occur after chimeric antigen receptor T cell (CAR T cell) infusion and represent a therapeutic challenge. Given the established link between perforin deficiency and primary...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Ishii, Kazusa, Pouzolles, Marie, Chien, Christopher D., Erwin-Cohen, Rebecca A., Kohler, M. Eric, Qin, Haiying, Lei, Haiyan, Kuhn, Skyler, Ombrello, Amanda K., Dulau-Florea, Alina, Eckhaus, Michael A., Shalabi, Haneen, Yates, Bonnie, Lichtenstein, Daniel A., Zimmermann, Valérie S., Kondo, Taisuke, Shern, Jack F., Young, Howard A., Taylor, Naomi, Shah, Nirali N., Fry, Terry J.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524496/
https://ncbi.nlm.nih.gov/pubmed/32925169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130059
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