CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial

PURPOSE: Patients with B-cell acute lymphoblastic leukemia who experience relapse after or are resistant to CD19-targeted immunotherapies have limited treatment options. Targeting CD22, an alternative B-cell antigen, represents an alternate strategy. We report outcomes on the largest patient cohort...

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Vydáno v:J Clin Oncol
Hlavní autoři: Shah, Nirali N., Highfill, Steven L., Shalabi, Haneen, Yates, Bonnie, Jin, Jianjian, Wolters, Pamela L., Ombrello, Amanda, Steinberg, Seth M., Martin, Staci, Delbrook, Cindy, Hoffman, Leah, Little, Lauren, Ponduri, Anusha, Qin, Haiying, Qureshi, Haris, Dulau-Florea, Alina, Salem, Dalia, Wang, Hao-Wei, Yuan, Constance, Stetler-Stevenson, Maryalice, Panch, Sandhya, Tran, Minh, Mackall, Crystal L., Stroncek, David F., Fry, Terry J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2020
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ORIGINAL REPORTS
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280047/
https://ncbi.nlm.nih.gov/pubmed/32286905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.19.03279
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