Impact of cytokine release syndrome on cardiac function following CD19 CAR-T cell therapy in children and young adults with hematological malignancies

BACKGROUND: Chimeric antigen receptor (CAR) T-cell-associated cytokine release syndrome (CRS) may present with tachycardia, hemodynamic instability and reduced cardiac function. Pediatric CAR studies examining cardiac toxicity are limited. METHODS: We report on cardiac toxicity observed in children...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Shalabi, Haneen, Sachdev, Vandana, Kulshreshtha, Amita, Cohen, Julia W, Yates, Bonnie, Rosing, Doug R, Sidenko, Stanislav, Delbrook, Cindy, Mackall, Crystal, Wiley, Brandon, Lee, Daniel W, Shah, Nirali N
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Clinical/Translational Cancer Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473612/
https://ncbi.nlm.nih.gov/pubmed/32883871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001159
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