Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes

Dengue virus (DENV) infection requires cholesterol as a proviral factor, although statin treatment did not show antiviral efficacy in patients with dengue. Here, we show that DENV infection manipulated cholesterol metabolism in cells residing in low-oxygen microenvironments (hypoxia) such as in the...

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Vydáno v:J Clin Invest
Hlavní autoři: Gan, Esther Shuyi, Tan, Hwee Cheng, Le, Duyen Huynh Thi, Huynh, Trieu Trung, Wills, Bridget, Seidah, Nabil G., Ooi, Eng Eong, Yacoub, Sophie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524462/
https://ncbi.nlm.nih.gov/pubmed/32644974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137536
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