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Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes
Dengue virus (DENV) infection requires cholesterol as a proviral factor, although statin treatment did not show antiviral efficacy in patients with dengue. Here, we show that DENV infection manipulated cholesterol metabolism in cells residing in low-oxygen microenvironments (hypoxia) such as in the...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7524462/ https://ncbi.nlm.nih.gov/pubmed/32644974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137536 |
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