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Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception(†)

Cyclin-dependent kinase 2 (CDK2) is a member of the larger cell cycle regulating CDK family of kinases, activated by binding partner cyclins as its name suggests. Despite its canonical role in mitosis, CDK2 knockout mice are viable but sterile, suggesting compensatory mechanisms for loss of CDK2 in...

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Podrobná bibliografie
Vydáno v:Biol Reprod
Hlavní autoři: Faber, Erik B, Wang, Nan, Georg, Gunda I
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523694/
https://ncbi.nlm.nih.gov/pubmed/32543655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioaa107
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