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γH2AX in the S Phase after UV Irradiation Corresponds to DNA Replication and Does Not Report on the Extent of DNA Damage

Ultraviolet (UV) radiation is a major environmental mutagen. Exposure to UV leads to a sharp peak of γH2AX, the phosphorylated form of the histone variant H2AX, in the S phase within an asynchronous population of cells. γH2AX is often considered a definitive marker of DNA damage inside a cell. In th...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Dhuppar, Shivnarayan, Roy, Sitara, Mazumder, Aprotim
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523655/
https://ncbi.nlm.nih.gov/pubmed/32778572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00328-20
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