Guanine-specific DNA damage induced by γ-irradiated histone

In γ-irradiation, (•)OH is directly generated from water and causes DNA damage leading to carcinogenesis. Exposure of proteins to γ-irradiation, in the presence of oxygen, gives high yields of hydroperoxides. To clarify whether these hydroperoxides, particularly those formed on DNA-binding histone p...

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Autores principales: Furukawa, Ayako, Hiraku, Yusuke, Oikawa, Shinji, Luxford, Catherine, Davies, Michael J., Kawanishi, Shosuke
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2005
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1183460/
https://ncbi.nlm.nih.gov/pubmed/15698381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050186
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