Treatment of an aggressive orthotopic murine glioblastoma model with combination checkpoint blockade and a multivalent neoantigen vaccine

BACKGROUND: Although clinical trials testing immunotherapies in glioblastoma (GBM) have yielded mixed results, new strategies targeting tumor-specific somatic coding mutations, termed “neoantigens,” represent promising therapeutic approaches. We characterized the microenvironment and neoantigen land...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Liu, Connor J, Schaettler, Maximilian, Blaha, Dylan T, Bowman-Kirigin, Jay A, Kobayashi, Dale K, Livingstone, Alexandra J, Bender, Diane, Miller, Christopher A, Kranz, David M, Johanns, Tanner M, Dunn, Gavin P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523441/
https://ncbi.nlm.nih.gov/pubmed/32133512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa050
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