Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death....

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Publicado en:medRxiv
Autores principales: Vella, Laura, Giles, Josephine R., Baxter, Amy E., Oldridge, Derek A, Diorio, Caroline, Kuri-Cervantes, Leticia, Alanio, Cecile, Pampena, Maria Betina, Wu, Jennifer E, Chen, Zeyu, Huang, Yinghui Jane, Anderson, Elizabeth M., Gouma, Sigrid, McNerney, Kevin O., Chase, Julie, Burudpakdee, Chakkapong, Lee, Jessica H., Apostolidis, Sokratis A., Huang, Alexander C., Mathew, Divij, Kuthuru, Oliva, Goodwin, Eileen C., Weirick, Madison E., Bolton, Marcus J., Arevalo, Claudia P., Ramos, Andre, Jasen, Cristina, Giannini, Heather M., DAndrea, Kurt, Meyer, Nuala J., Behrens, Edward M., Bassiri, Hamid, Hensley, Scott E., Henrickson, Sarah E., Teachey, David T., Betts, Michael R., Wherry, E. John
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523167/
https://ncbi.nlm.nih.gov/pubmed/32995826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.09.25.20201863
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