Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death....

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Gepubliceerd in:Sci Immunol
Hoofdauteurs: Vella, Laura A., Giles, Josephine R., Baxter, Amy E., Oldridge, Derek A., Diorio, Caroline, Kuri-Cervantes, Leticia, Alanio, Cécile, Pampena, M. Betina, Wu, Jennifer E., Chen, Zeyu, Huang, Yinghui Jane, Anderson, Elizabeth M., Gouma, Sigrid, McNerney, Kevin O., Chase, Julie, Burudpakdee, Chakkapong, Lee, Jessica H., Apostolidis, Sokratis A., Huang, Alexander C., Mathew, Divij, Kuthuru, Oliva, Goodwin, Eileen C., Weirick, Madison E., Bolton, Marcus J., Arevalo, Claudia P., Ramos, Andre, Jasen, CJ, Conrey, Peyton E, Sayed, Samir, Giannini, Heather M., D’Andrea, Kurt, Meyer, Nuala J., Behrens, Edward M., Bassiri, Hamid, Hensley, Scott E., Henrickson, Sarah E., Teachey, David T., Betts, Michael R., Wherry, E. John
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2021
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128303/
https://ncbi.nlm.nih.gov/pubmed/33653907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abf7570
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