Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection

HIV-1 cell entry is mediated by binding to the CD4-receptor and chemokine co-receptors CCR5 (R5) or CXCR4 (X4). R5-tropic viruses are predominantly detected during early infection. A switch to X4-tropism often occurs during the course of infection. X4-tropism switching is strongly associated with ac...

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Udgivet i:Sci Rep
Main Authors: Connell, Bridgette J., Hermans, Lucas E., Wensing, Annemarie M. J., Schellens, Ingrid, Schipper, Pauline J., van Ham, Petra M., de Jong, Dorien T. C. M., Otto, Sigrid, Mathe, Tholakele, Moraba, Robert, Borghans, José A. M., Papathanasopoulos, Maria A., Kruize, Zita, Venter, Francois W. D., Kootstra, Neeltje A., Tempelman, Hugo, Tesselaar, Kiki, Nijhuis, Monique
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522993/
https://ncbi.nlm.nih.gov/pubmed/32985522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71699-z
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