Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways

OBJECTIVE: The aim of this study was to eluc\idate the preventive and therapeutic effects and the underlying mechanisms of Huoxue Huatan Decoction (HXHT) on myocardial ischemia/reperfusion (I/R) injury in hyperlipidemic rats. METHODS: An I/R model was established in hyperlipidemic Wistar rats. After...

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Vydáno v:Front Pharmacol
Hlavní autoři: Lin, Fei, Tan, Yu-Qing, He, Xuan-Hui, Guo, Li-Li, Wei, Ben-Jun, Li, Jun-Ping, Chen, Zhong, Chen, Heng-Wen, Wang, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522555/
https://ncbi.nlm.nih.gov/pubmed/33041792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.546825
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