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Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria
Similar to DNA replication, translation of the genetic code by the ribosome is hypothesized to be exceptionally sensitive to small chemical changes to its template mRNA. Here we show that the addition of common alkylating agents to growing cultures of Escherichia coli leads to the accumulation of se...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7521929/ https://ncbi.nlm.nih.gov/pubmed/32940602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61984 |
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