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Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes

Mechanical stimulation of fibroblasts induces changes in the actin cytoskeleton including stress fiber (SF) reinforcement and realignment. Here we characterize the nuclear response to mechanical stimulation (uniaxial cyclic stretch). Using fluorescence microscopy and quantitative image analysis we f...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Hoffman, Laura M., Smith, Mark A., Jensen, Christopher C., Yoshigi, Masaaki, Blankman, Elizabeth, Ullman, Katharine S., Beckerle, Mary C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521858/
https://ncbi.nlm.nih.gov/pubmed/31967947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-01-0027
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