Characterization of a TP53 Somatic Variant of Unknown Function From an Ovarian Cancer Patient Using Organoid Culture and Computational Modeling

In our proof-of-concept study of 1 patient with stage IIIC carcinosarcoma of the ovary, we discovered a rare mutation in the tumor suppressor, TP53, that results in the deletion of N131. Immunofluorescence imaging of the organoid culture revealed hyperstaining of p53 protein. Computational modeling...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Obstet Gynecol
Prif Awduron: BI, JIANLING, THIEL, KRISTINA W., LITMAN, JACOB M., ZHANG, YUPING, DEVOR, ERIC J., NEWTSON, ANDREEA M., SCHNIEDERS, MICHAEL J., BOSQUET, JESUS GONZALEZ, LESLIE, KIMBERLY K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521672/
https://ncbi.nlm.nih.gov/pubmed/31876640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/GRF.0000000000000516
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