TP53 oncomorphic mutations predict resistance to platinum- and taxane-based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma

Individual mutations in the tumor suppressor TP53 alter p53 protein function. Some mutations create a non-functional protein, whereas others confer oncogenic activity, which we term ‘oncomorphic’. Since mutations in TP53 occur in nearly all ovarian tumors, the objective of this study was to determin...

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Detalhes bibliográficos
Publicado no:Int J Oncol
Main Authors: BRACHOVA, PAVLA, MUETING, SAMUEL R., CARLSON, MATTHEW J., GOODHEART, MICHAEL J., BUTTON, ANNA M., MOTT, SARAH L., DAI, DONGHAI, THIEL, KRISTINA W., DEVOR, ERIC J., LESLIE, KIMBERLY K.
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277253/
https://ncbi.nlm.nih.gov/pubmed/25385265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2747
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