CB(1) receptor‐dependent desensitisation of TRPV1 channels contributes to the analgesic effect of dipyrone in sensitised primary sensory neurons

BACKGROUND AND PURPOSE: While dipyrone is a widely used analgesic, its mechanism of action is not completely understood. Recently, we have reported that the dipyrone metabolite 4‐aminoantipyrine (4‐AA) reduces PGE(2)‐induced pain‐related behaviour through cannabinoid CB(1) receptors. Here, we ascert...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Goncalves dos Santos, Gilson, Li, Ruihui, Ng, Melissa Pui Een, Lemes, Julia Borges Paes, Vieira, Willians Fernando, Nagy, Istvan, Tambeli, Cláudia Herrera, Parada, Carlos Amilcar
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7520441/
https://ncbi.nlm.nih.gov/pubmed/32562269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15170
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