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A dyadic genotype–phenotype approach to diagnostic criteria for Proteus syndrome

Phenotype-based diagnostic criteria were developed for Proteus syndrome in 1999 and updated in 2006. Subsequently, the causative mosaic gene alteration was discovered, the c.49G>A p.E17K variant in AKT1. As well, a number of overlapping overgrowth disorders attributable to mosaic PIK3CA variants...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Med Genet C Semin Med Genet
Prif Awduron: Sapp, Julie C., Buser, Anna, Burton-Akright, Jasmine, Keppler-Noreuil, Kim M., Biesecker, Leslie G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7520016/
https://ncbi.nlm.nih.gov/pubmed/31692258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.c.31744
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