Plasmacytoid dendritic cells cross-prime naive CD8 T cells by transferring antigen to conventional dendritic cells through exosomes

Although plasmacytoid dendritic cells (pDCs) have been shown to play a critical role in generating viral immunity and promoting tolerance to suppress antitumor immunity, whether and how pDCs cross-prime CD8 T cells in vivo remain controversial. Using a pDC-targeted vaccine model to deliver antigens...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Fu, Chunmei, Peng, Peng, Loschko, Jakob, Feng, Li, Pham, Phuong, Cui, Weiguo, Lee, Kelvin P., Krug, Anne B., Jiang, Aimin
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519282/
https://ncbi.nlm.nih.gov/pubmed/32879009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002345117
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