A trimeric CrRLK1L-LLG1 complex genetically modulates SUMM2-mediated autoimmunity

Cell death is intrinsically linked with immunity. Disruption of an immune-activated MAPK cascade, consisting of MEKK1, MKK1/2, and MPK4, triggers cell death and autoimmunity through the nucleotide-binding leucine-rich repeat (NLR) protein SUMM2 and the MAPK kinase kinase MEKK2. In this study, we ide...

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Udgivet i:Nat Commun
Main Authors: Huang, Yanyan, Yin, Chuanchun, Liu, Jun, Feng, Baomin, Ge, Dongdong, Kong, Liang, Ortiz-Morea, Fausto Andres, Richter, Julia, Hauser, Marie-Theres, Wang, Wen-Ming, Shan, Libo, He, Ping
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519094/
https://ncbi.nlm.nih.gov/pubmed/32978401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18600-8
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