SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells

SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High SOX11 levels in breast tumours are significantly associated with distant metastasis and poor outcome in breast cancer patients. Here, we show that SOX11 confers distinct features to ER-negative DCIS.com br...

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Udgivet i:eLife
Main Authors: Oliemuller, Erik, Newman, Richard, Tsang, Siu Man, Foo, Shane, Muirhead, Gareth, Noor, Farzana, Haider, Syed, Aurrekoetxea-Rodríguez, Iskander, Vivanco, Maria dM, Howard, Beatrice A
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518891/
https://ncbi.nlm.nih.gov/pubmed/32909943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58374
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