Variants of the human RAD52 gene confer defects in ionizing radiation resistance and homologous recombination repair in budding yeast

RAD52 is a structurally and functionally conserved component of the DNA double-strand break (DSB) repair apparatus from budding yeast to humans. We recently showed that expressing the human gene, HsRAD52 in rad52 mutant budding yeast cells can suppress both their ionizing radiation (IR) sensitivity...

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Veröffentlicht in:Microb Cell
Hauptverfasser: Clear, Alissa D., Manthey, Glenn M., Lewis, Olivia, Lopez, Isabelle Y., Rico, Rossana, Owens, Shannon, Negritto, M. Cristina, Wolf, Elise W., Xu, Jason, Kenjić, Nikola, Perry, J. Jefferson P., Adamson, Aaron W., Neuhausen, Susan L., Bailis, Adam M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Shared Science Publishers OG 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7517009/
https://ncbi.nlm.nih.gov/pubmed/33015141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2020.10.732
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