Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity

Dityrosine (DiY), via the cross-linking of tyrosine residues, is a marker of protein oxidation, which increases with aging. Amyloid-β (Aβ) forms DiY in vitro and DiY-cross-linked Aβ is found in the brains of patients with Alzheimer disease. Metal- or UV- catalyzed oxidation of Aβ42 results in an inc...

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Vydáno v:iScience
Hlavní autoři: Maina, Mahmoud B., Burra, Gunasekhar, Al-Hilaly, Youssra K., Mengham, Kurtis, Fennell, Kate, Serpell, Louise C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516296/
https://ncbi.nlm.nih.gov/pubmed/33083713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101537
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