Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren’s syndrome

OBJECTIVE: Salivary gland (SG) progenitor cells (SGPCs) maintain SG homeostasis. We have previously shown that in primary Sjögren’s syndrome (pSS), SGPCs are likely to be senescent, and may underpin SG dysfunction. This study assessed the extent of senescence of cells in a SGPC niche in pSS patients...

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Dettagli Bibliografici
Pubblicato in:Rheumatology (Oxford)
Autori principali: Wang, Xiaoyan, Bootsma, Hendrika, Terpstra, Janneke, Vissink, Arjan, van der Vegt, Bert, Spijkervet, Fred K L, Kroese, Frans G M, Pringle, Sarah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Clinical Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516109/
https://ncbi.nlm.nih.gov/pubmed/32159757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keaa012
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