Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren’s syndrome

OBJECTIVE: Salivary gland (SG) progenitor cells (SGPCs) maintain SG homeostasis. We have previously shown that in primary Sjögren’s syndrome (pSS), SGPCs are likely to be senescent, and may underpin SG dysfunction. This study assessed the extent of senescence of cells in a SGPC niche in pSS patients...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: Wang, Xiaoyan, Bootsma, Hendrika, Terpstra, Janneke, Vissink, Arjan, van der Vegt, Bert, Spijkervet, Fred K L, Kroese, Frans G M, Pringle, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Clinical Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516109/
https://ncbi.nlm.nih.gov/pubmed/32159757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keaa012
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