Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren’s syndrome

OBJECTIVE: Salivary gland (SG) progenitor cells (SGPCs) maintain SG homeostasis. We have previously shown that in primary Sjögren’s syndrome (pSS), SGPCs are likely to be senescent, and may underpin SG dysfunction. This study assessed the extent of senescence of cells in a SGPC niche in pSS patients...

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Détails bibliographiques
Publié dans:Rheumatology (Oxford)
Auteurs principaux: Wang, Xiaoyan, Bootsma, Hendrika, Terpstra, Janneke, Vissink, Arjan, van der Vegt, Bert, Spijkervet, Fred K L, Kroese, Frans G M, Pringle, Sarah
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Clinical Science
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516109/
https://ncbi.nlm.nih.gov/pubmed/32159757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keaa012
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