Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren’s syndrome

OBJECTIVE: Salivary gland (SG) progenitor cells (SGPCs) maintain SG homeostasis. We have previously shown that in primary Sjögren’s syndrome (pSS), SGPCs are likely to be senescent, and may underpin SG dysfunction. This study assessed the extent of senescence of cells in a SGPC niche in pSS patients...

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Dades bibliogràfiques
Publicat a:Rheumatology (Oxford)
Autors principals: Wang, Xiaoyan, Bootsma, Hendrika, Terpstra, Janneke, Vissink, Arjan, van der Vegt, Bert, Spijkervet, Fred K L, Kroese, Frans G M, Pringle, Sarah
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Clinical Science
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516109/
https://ncbi.nlm.nih.gov/pubmed/32159757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keaa012
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