Topical ripasudil stimulates neuroprotection and axon regeneration in adult mice following optic nerve injury

Optic nerve injury induces optic nerve degeneration and retinal ganglion cell (RGC) death that lead to visual disturbance. In this study, we examined if topical ripasudil has therapeutic potential in adult mice after optic nerve crush (ONC). Topical ripasudil suppressed ONC-induced phosphorylation o...

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Vydáno v:Sci Rep
Hlavní autoři: Nishijima, Euido, Namekata, Kazuhiko, Kimura, Atsuko, Guo, Xiaoli, Harada, Chikako, Noro, Takahiko, Nakano, Tadashi, Harada, Takayuki
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515881/
https://ncbi.nlm.nih.gov/pubmed/32973242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72748-3
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