MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development. We showed that knockdown of mondoa impaired the early morphogenetic movement...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Weger, Meltem, Weger, Benjamin D, Schink, Andrea, Takamiya, Masanari, Stegmaier, Johannes, Gobet, Cédric, Parisi, Alice, Kobitski, Andrei Yu, Mertes, Jonas, Krone, Nils, Strähle, Uwe, Nienhaus, Gerd Ulrich, Mikut, Ralf, Gachon, Frédéric, Gut, Philipp, Dickmeis, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515633/
https://ncbi.nlm.nih.gov/pubmed/32969791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57068
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