Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na(v)1.5

The cardiac voltage-gated sodium channel Na(v)1.5 conducts the rapid inward sodium current crucial for cardiomyocyte excitability. Loss-of-function mutations in its gene SCN5A are linked to cardiac arrhythmias such as Brugada Syndrome (BrS). Several BrS-associated mutations in the Na(v)1.5 N-termina...

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Vydáno v:Channels (Austin)
Hlavní autoři: Wang, Zizun, Vermij, Sarah H., Sottas, Valentin, Shestak, Anna, Ross-Kaschitza, Daniela, Zaklyazminskaya, Elena V., Hudmon, Andy, Pitt, Geoffrey S., Rougier, Jean-Sébastien, Abriel, Hugues
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515574/
https://ncbi.nlm.nih.gov/pubmed/32815768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2020.1805999
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