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APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis
Sporadic colorectal cancer initiates with mutations in APC or its degradation target β-catenin, producing TCF-dependent nuclear transcription driving tumorigenesis. The intestinal epithelial receptor, GUCY2C, with its canonical paracrine hormone guanylin, regulates homeostatic signaling along the cr...
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| Publicado no: | Cancer Biol Ther |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7515458/ https://ncbi.nlm.nih.gov/pubmed/32037952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2020.1721262 |
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