APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis

Sporadic colorectal cancer initiates with mutations in APC or its degradation target β-catenin, producing TCF-dependent nuclear transcription driving tumorigenesis. The intestinal epithelial receptor, GUCY2C, with its canonical paracrine hormone guanylin, regulates homeostatic signaling along the cr...

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Publicat a:Cancer Biol Ther
Autors principals: Blomain, Erik S., Rappaport, Jeffrey A., Pattison, Amanda M., Bashir, Babar, Caparosa, Ellen, Stem, Jonathan, Snook, Adam E., Waldman, Scott A.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515458/
https://ncbi.nlm.nih.gov/pubmed/32037952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2020.1721262
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