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Hybrid semiparametric systems for quantitative sequence-activity modeling of synthetic biological parts

Predicting the activity of modified biological parts is difficult due to the typically large size of nucleotide sequences, resulting in combinatorial designs that suffer from the “curse of dimensionality” problem. Mechanistic design methods are often limited by knowledge availability. Empirical meth...

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Dettagli Bibliografici
Pubblicato in:Synth Biol (Oxf)
Autori principali: Portela, Rui M C, von Stosch, Moritz, Oliveira, Rui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513808/
https://ncbi.nlm.nih.gov/pubmed/32995518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/synbio/ysy010
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