Antibody Screening Using a Human iPSC-based Blood-Brain Barrier Model Identifies Antibodies that Accumulate in the CNS

Drug delivery across the blood-brain barrier (BBB) remains a significant obstacle for the development of neurological disease therapies. The low penetration of blood-borne therapeutics into the brain can oftentimes be attributed to the restrictive nature of the brain microvascular endothelial cells...

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Détails bibliographiques
Publié dans:FASEB J
Auteurs principaux: Georgieva, Julia V., Goulatis, Loukas I., Stutz, Charles C., Canfield, Scott G., Song, Hannah W., Gastfriend, Benjamin D., Shusta, Eric V.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513543/
https://ncbi.nlm.nih.gov/pubmed/32960493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202000851R
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