Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade

Glioblastoma (GBM) is the most aggressive primary brain tumor. In addition to being genetically heterogeneous, GBMs are also immunologically heterogeneous. However, whether the differences in immune microenvironment are driven by genetic driver mutation is unexplored. By leveraging the versatile RCA...

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Detalhes bibliográficos
Publicado no:Glia
Main Authors: Chen, Zhihong, Herting, Cameron J., Ross, James L., Gabanic, Ben, Vallcorba, Montse Puigdelloses, Szulzewsky, Frank, Wojciechowicz, Megan L., Cimino, Patrick J., Ezhilarasan, Ravesanker, Sulman, Erik P., Ying, Mingyao, Ma’ayan, Avi, Read, Renee D., Hambardzumyan, Dolores
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7512141/
https://ncbi.nlm.nih.gov/pubmed/32639068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23883
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