Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade

Glioblastoma (GBM) is the most aggressive primary brain tumor. In addition to being genetically heterogeneous, GBMs are also immunologically heterogeneous. However, whether the differences in immune microenvironment are driven by genetic driver mutation is unexplored. By leveraging the versatile RCA...

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Gepubliceerd in:Glia
Hoofdauteurs: Chen, Zhihong, Herting, Cameron J., Ross, James L., Gabanic, Ben, Vallcorba, Montse Puigdelloses, Szulzewsky, Frank, Wojciechowicz, Megan L., Cimino, Patrick J., Ezhilarasan, Ravesanker, Sulman, Erik P., Ying, Mingyao, Ma’ayan, Avi, Read, Renee D., Hambardzumyan, Dolores
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7512141/
https://ncbi.nlm.nih.gov/pubmed/32639068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23883
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