Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade

Glioblastoma (GBM) is the most aggressive primary brain tumor. In addition to being genetically heterogeneous, GBMs are also immunologically heterogeneous. However, whether the differences in immune microenvironment are driven by genetic driver mutation is unexplored. By leveraging the versatile RCA...

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Détails bibliographiques
Publié dans:Glia
Auteurs principaux: Chen, Zhihong, Herting, Cameron J., Ross, James L., Gabanic, Ben, Vallcorba, Montse Puigdelloses, Szulzewsky, Frank, Wojciechowicz, Megan L., Cimino, Patrick J., Ezhilarasan, Ravesanker, Sulman, Erik P., Ying, Mingyao, Ma’ayan, Avi, Read, Renee D., Hambardzumyan, Dolores
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7512141/
https://ncbi.nlm.nih.gov/pubmed/32639068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23883
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