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Effects of omecamtiv mecarbil on calcium‐transients and contractility in a translational canine myocyte model

Omecamtiv mecarbil (OM) is a selective cardiac myosin activator (myotrope), currently in Phase 3 clinical investigation as a novel treatment for heart failure with reduced ejection fraction. OM increases cardiac contractility by enhancing interaction between myosin and actin in a calcium‐independent...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Gao, BaoXi, Sutherland, Weston, Vargas, Hugo M., Qu, Yusheng
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7512116/
https://ncbi.nlm.nih.gov/pubmed/32969560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.656
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